Research
Interest
Lipid activators of endothelium in atherosclerosis
Representative
Publications
Yeh
M, Leitinger N, de Martin R, Onai N, Matsushima K, Vora DK, Berliner
JA, Reddy ST. Increased transcription of IL-8 in endothelial
cells is differentially regulated by TNF-alpha and oxidized
phospholipids. Arterioscler
Thromb Vasc Biol. 2001;21:1585-91.
Subbanagounder
G, Wong JW, Lee H, Faull KF, Miller E, Witztum JL, Berliner JA.
Epoxyisoprostane and epoxycyclopentenone phospholipids regulate
monocyte chemotactic protein-1 and interleukin-8 synthesis.
Formation of these oxidized phospholipids in response to
interleukin-1beta. J Biol
Chem. 2002;277:7271-81.
Lee
H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama
S, Borromeo C, Evans RM, Berliner JA, Nagy L. Role for
peroxisome proliferator-activated receptor alpha in oxidized
phospholipid-induced synthesis of monocyte chemotactic protein-1
and interleukin-8 by endothelial cells. Circ
Res. 2000;87:516-21.
Subbanagounder
G, Leitinger N, Schwenke DC, Wong JW, Lee H, Rizza C, Watson AD,
Faull KF, Fogelman AM, Berliner JA. Determinants of
bioactivity of oxidized phospholipids. Specific oxidized fatty
acyl groups at the sn-2 position. Arterioscler Thromb Vasc Biol. 2000;20:2248-54.
Honda
HM, Leitinger N, Frankel M, Goldhaber JI, Natarajan R, Nadler JL,
Weiss JN, Berliner JA. Induction of monocyte binding to
endothelial cells by MM-LDL: role of lipoxygenase metabolites. Arterioscler
Thromb Vasc Biol. 1999;19:680-6. |
