Research
Interest
Cardiovascular
pathophysiology with focus on nitric oxide and reactive oxygen
species signaling in models of hypertension, atherosclerosis,
diabetic vascular diseases and therapeutic angiogenesis.
Representative
Publications
Oak JH, Cai H.
Attenuation of angiotensin II signaling recouples eNOS and inhibits
non-endothelial NOX activity in diabetic mice. Diabetes
2007Jan;56(1): 118-126
Zhang G, Zhang F, Muh,
R, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of
superoxide production through NAD(P)H oxidase in coronary arterial
myocytes. Am. J. Physiol. Heart Circ. Physiol. 2007Jan;292(1):
H483-95
Nguyen A, Cai H.
Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS
feed-forward mechanism. Proc Natl Acad Sci U S A.
2006Apr;103(17):6530-5
Cai H. A new
mechanism for flow-mediated vasoprotection? Am. J. Physiol. Cell
Physiol. Editorial Focus on “Lung endothelial cell proliferation
with decreased shear stress is mediated by reactive oxygen species”.
2006 Jan;290(1):C35-6
Menshikov M,
Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P,
Tkachuk V, Berk BC. Urokinase stimulates vascular smooth muscle
proliferation via redox-sensitive pathways. Arterioscler. Thromb.
Vasc. Biol. 2006April;26(4):801-7
Cai H. Hydrogen
peroxide regulation of endothelial function: Origins, mechanisms and
consequences. Cardiovasc. Res. 2005Oct;68(1):26-36.
Chalupsky K and Cai
H. Endothelial dihydrofolate reductase: critical for nitric oxide
bioavailability and role in angiotensin II uncoupling of eNOS. Proc
Natl Acad Sci U S A. 2005June;102(25):9056-61.
Cai H NAD(P)H oxidase-dependent
self-propagation of hydrogen peroxide and vascular disease. Cir.
Res. 2005April;96(8):818-822.
Nakagawa K, Oak JH,
Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H, Miyazawa T.
Ion trap tandem mass spectrometric evidence for the presence of
Amadori-glycated phosphatidulethanolamine, a lipid-linked glycation
compound, in plasma of humans with or without diabetes. J Lipid Res.
2005Nov;46(11)2514-24
Nguyen A, Chen P, Cai
H. Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38
MAPK, HSP27 and actin reorganization in endothelial cells. FEBS Lett.
2004Aug;572(1-3):307-13
Cai H, McNally JS,
Weber M, Harrison DG. Oscillatory shear stress regulation of
endothelial nitric oxide synthase requires intracellular hydrogen
peroxide and CaMKII. J. Mol. Cell. Cardiol. 2004Jul;37(1):121-5
McNally JS, Saxena A,
Cai H, Dikalov S, Harrison DG. Regulation of xanthine oxidoreductase
protein expression by hydrogen peroxide and calcium. Arterioscler.
Thromb. Vasc. Biol. 2005Aug;25(8):1623-8.
Laude K, Cai H, Fink
B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Dikalov S, Ramasamy
S, Gamez G, Griendling KK, Harrison DG. Hemodynamic and biochemical
adaptations to vascular smooth muscle overexpression of p22phox in
mice. Am. J. Physiol. Heart Circ. Physiol. 2005Jan;288(1):H7-H12
Searles CD, Ide L,
Davis, ME, Cai H, Weber M. Actin cytoskeleton organization and
post-transcriptional regulation of endothelial nitric oxide synthase
during cell growth. Cir. Res. 2004Sept;95(5):488-95
Cai H, Griendling KK,
Harrison DG. Angiotensin II induced vascular NAD(P)H oxidases as
therapeutic targets in cardiovascular disease. Trends in
Pharmacological Science 2003Sep;24(9):471-8
Harrison DG, Cai H,
Landmesser U, Griendling KK. Interaction of angiotensin II with
NAD(P)H oxidase, oxidant stress and cardiovascular disease. The
Journal of the Renin-Angiotensin-Aldosterone System
2003Jun;4(2):51-61
Harrison DG, Cai H.
Endothelium control of vascomotion and nitric oxide production.
Cardiology Clinics 2003Aug;21(3):289-302
Cai H, Li Z, Davis
ME, Kanner W, Harrison DG, Dudley SC. Akt-dependent phosphorylation
of serine 1179 and MEK/ERK 1/2 cooperatively mediates activation of
the endothelial nitric oxide synthase by hydrogen peroxide.
Molecular Pharmacology 2003Feb;63(2): 325-331
Davis ME, Cai H,
McCann L, Fukai T, Harrison DG. Role of c-Src in regulation of
endothelial nitric oxide synthase expression during exercise
training. Am. J. Physiol. Heart Circ. Physiol.
2003Apr;284(4):H1449-53.
Cai H, Li Z, Goette
A, Mera F, Honeycutt C, Feterik K, Dudley SC, Harrison DG, Langberg
JJ. Downregulation of endocardial nitric oxide synthase expression
and nitric oxide production in atrial fibrillation. Potential
mechanisms for atrial thrombosis and stroke. Circulation
2002Nov;106(22):2854-2858.
Cai H, Li Z, Dikalov
S, Holland SM, Hwang J, Jo H, Dudley SC, Harrison D. NAD(P)H oxidase-derived
hydrogen peroxide mediates endothelial nitric oxide production of in
response to angiotensin II. J. Biol. Chem.
2002Dec;277(50):48311-48317.
Landmesser U, Cai H,
Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG. Role of
p47phox in vascular oxidative stress and hypertension caused by
angiotensin II. Hypertension 2002Oct;40(4): 511-515.
Davis ME, Cai H,
Drummond GR, Harrison DG. Shear stress regulates endothelial nitric
oxide synthase expression through c-Src by divergent signaling
pathways. Cir. Res. 2001Nov;89(11): 1073-80.
Cai H, Davis ME,
Drummond GR, Harrison DG. Induction of endothelial NO synthase by
hydrogen peroxide via a Ca2+/camodulin-dependent protein kinase II/janus
kinase 2-dependent pathway. Arterioscler. Thromb. Vasc. Biol.
2001Oct;21(10): 1571-6.
Cai H, Harrison DG. Endothelial dysfunction in cardiovascular
diseases. The role of oxidant stress. Cir. Res. 2000Nov;87(10):
840-4.
Drummond GR, Cai H,
Davis ME, Ramasamy S, Harrison DG. Transcriptional and
posttranscriptional regulation of endothelial nitric oxide synthase
expression by hydrogen peroxide. Cir. Res. 2000Feb;86(3): 347-354.
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