Research
Interest
Cholesterol and isoprenoid metabolism in atherosclerosis.
Representative
Publications
Kennedy,
M.A., Venkateswaran, A., Tarr, P. T., Xenarios, I., Kudoh, J.,
Shimizu, N., and Edwards, P. A. (2001) Characterization of
the Human ABCG1 Gene; LXR activates an internal promoter that
produces a novel transcript encoding an alternative form of the
protein. Journal of Biological Chemistry in press:.
Chawla,
A., Boisvert, W. A., Lee, C-H., Laffitte, B. A., Barak, Y.,
Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss,
L. K., Evans, R. M., Tontonoz, P. (2001) A PPARg-LXR-ABCA1 Pathway
in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis.
Molecular Cell 7: 161-171.
Kast,
H. R., Nguyen, C. M., Sinal, C. J., Jones, S. A., Laffitte, B. A.,
Reue, K., Gonzalez, F. J., Willson, T. M., Edwards, P. A.
(2001) Farnesoid X-Activated Receptor Induces Apolipoprotein C-II
Transcription: a Molecular Mechanism Linking Plasma Triglyceride
Levels to Bile Acids. Molecular Endocrinology in press:.
Venkateswaran,
A., Repa, J.J., Lobaccaro, J-M.A., Bronson, A., Mangelsdorf, D.J.,
Edwards, P.A. (2000) Human White/Murine ABC8 mRNA Levels are
Highly Induced in Lipid-loaded Macrophages. Journal of Biological
Chemistry 275: 14700-14707.
Venkateswaran,
A., Laffitte, B.A., Joseph, S.B., Mak, P.A., Wilpitz, D.C., Edwards,
P.A. and Tontonoz, P. (2000) Control of Cellular Cholesterol
Efflux by the Nuclear Receptor LXRa. Proceedings of the National
Academy of Sciences, USA 97: 12097-12102.
Edwards,
P. A. and Ericsson, J. (1999) Sterols and Isoprenoids:
Signaling Molecules derived from the Cholesterol Biosynthetic
Pathway. Ann. Rev. Biochem. 68: 157-185.
|
