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Faculty
 

Alan Garfinkel, Ph.D.
Curriculum Vitae

 
Education

1975 

Ph.D.
Harvard University Cambridge, Massachusetts    

1966 - 1968

Massachusetts Institute of Technology
Cambridge, Massachusetts

1966

A.B.
Cornell University Ithaca, New York (with distinction)

Positions

2003-Present

Professor, Department of Medicine (Cardiology) and Department of Physiological Science
University of California, Los Angeles

1999-2003

Associate Professor, Department of Medicine (Cardiology) and Department of Physiological Science
University of California, Los Angeles

1995-1999

Assistant Professor, Departments of Medicine (Cardiology) and Physiological Science
University of California, Los Angeles 

1986-Present

Member, Brain Research Institute
University of California, Los Angeles 

1976-1995

Associate Professor of Philosophy
California State University, Northridge 

1983-1985

Institute Research Scientist, Crump Institute for Medical Engineering
University of California, Los Angeles 

1979-1980

Visiting Associate Professor
University of California, Santa Cruz 

1972-1976

Assistant Professor of Philosophy
California State University, Northridge

Honors

1966-1967 

Woodrow Wilson Fellow 

1981-1982

National Endowment for the Humanities Year Fellowship

Selected Publications

  1. Garfinkel, A. A mathematics for physiology. Am. J. Physiol., Reg. Integ. Comp. Physiol. 245(14): R455-R466, 1983.

  2. Abraham, R., and A. Garfinkel. CORTISIM: A dynamic model of cortisol regulation. Simulation 47.5:199-207, 1986.

  3. Garfinkel, A. The virtues of chaos. Behavioral and Brain Sciences 10:178-179, 1987.

  4. Bodine, S., A. Garfinkel, R.Roy, and V.R. Edgerton. Spatial patterns of single motor unit fibers in the cat soleus and tibialis anterior muscles: local patterns. J. Neuroscience 8(6):2142-52, 1988.

  5. Winstein, C., and A. Garfinkel. Qualitative dynamics of disordered human locomotion: a preliminary investigation. J. Motor Behavior 21(4):373-391, 1989.

  6. Bodine-Fowler, S., Garfinkel, A. , Roy, Roland R., and Edgerton, V. Reggie. Spatial distribution of muscle fibers within the territory of a motor unit. Muscle and Nerve 13:1133-1145, 1990.

  7. Ounjian, M., R.R. Roy, E. Eldred, A Garfinkel, J.R. Payne, A. Armstrong, A. Toga, and V.R. Edgerton Physiological and Developmental Implications of Motor Unit Anatomy. J. Neurobiol. 22:547-559, 1991.

  8. Garfinkel, A. , D.O. Walter, R.B. Trelease, R.K. Harper, and R.M. Harper. Nonlinear dynamics of electrocardiographic waveforms following cocaine administration. Life Sciences 48:2189-93, 1991.

  9. Raetz, S.L., C.A. Richard, A. Garfinkel, and R.M. Harper. Dynamic characteristics of cardiac R-R intervals during sleep and waking states. Sleep 14(6):526-533, 1991.

  10. Ehlers, C.L., J.W. Havstad, A. Garfinkel and D. Kupfer. Nonlinear analysis of EEG sleep states. Neuropsychopharmacology 5: 167-176, 1991.

  11. Garfinkel, A. , S.L. Raetz, and R.M. Harper. Heart rate dynamics after acute cocaine administration. J. Cardiovascular Pharmacology 19:453-459, 1992.

  12. A. Garfinkel, M.L. Spano, W.L. Ditto and J.N. Weiss. Controlling cardiac chaos. Science 257: 1230-1235, 1992.

  13. V. Schectman, S.L. Raetz, R.K. Harper, A. Garfinkel, A. J. Wilson, D.P. Southall and R.M. Harper. Dynamic analysis of cardiac R-R intervals in normal infants and in infants who subsequently succumbed to the Sudden Infant Death Syndrome. Pediatric Research 31: 606-612, 1992.

  14. Eldred E; Garfinkel A; Hsu ES; Ounjian M; Roy RR; Edgerton. The physiological cross-sectional area of motor units in the cat tibialis anterior muscle Anatomical Record, 1993 Mar, 235(3):381-9.

  15. Weiss, James N., Alan Garfinkel, Mark L. Spano and William L. Ditto. Chaos and chaos control in biology. J. Clin. Invest. 93: 1355-1360 (and cover), 1994.

  16. Bacallao, R., Garfinkel, A. , Monke, S., Zampighi, G and Mandel, L. ATP depletion: a novel method to study junctional properties in epithelial tissues. J.Cell.Sci 107: 3301-3313, 1994.

  17. Garfinkel, Alan, James N. Weiss, Mark L. Spano and William L. Ditto. Chaos control of cardiac arrhythmias. Trends in Cardiovascular Medicine 5: 76-80, 1995.

  18. Roy, Roland R., Alan Garfinkel, Melinda Ounjian, Jeremy Payne, Alan Hirahara, Emmie Hsu, and V. Reggie Edgerton. Three-dimensional structure of cat tibialis anterior motor units. Muscle and Nerve 18: 1187-1195, 1995.

  19. Gaesser GA; Carnevale TJ; Garfinkel A; Walter DO; Womack CJ. Estimation of critical power with nonlinear and linear models. Medicine and Science in Sports and Exercise, 1995 Oct, 27(10):1430-8.

  20. Frank, J.S., Chen, F., Garfinkel, A. , Moore, E. Phillipson,K.D. Immunolocalization of the Na(+)-Ca2+ exchanger in cardiac myocytes. Annals of the New York Academy of Sciences 779: 532-33, 1996.

  21. Nguyen, Alison H., Alan Garfinkel, Donald O. Walter, Michele Hamilton, Gregg C. Fonarow, Jaime D. Moriguchi, Antoine Hage, James N. Weiss, and Holly R. Middlekauff. Dynamics of muscle sympathetic nerve activity in advanced heart failure patients. Am. J. Physiol. 271 (Heart Circ. Physiol. 40) : H1962-H1969, 1996

  22. Alan Garfinkel, Peng S. Chen, Donald O. Walter, Hrayr S. Karagueuzian, Boris Kogan, Steven J. Evans, Mikhail Karpoukhin, Chun Hwang, Takumi Uchida, Masamichi Gotoh, Obi Nwasokwa, Philip Sager and James N. Weiss. Quasiperiodicity and chaos in cardiac fibrillation. J. Clin. Inv . 99(2): 305-314, (and cover), 1997

  23. Qu, Zhilin, James N. Weiss and Alan Garfinkel. Spatiotemporal chaos in a simulated ring of cardiac cells. Phys. Rev. Lett. 78: 1387-1390, 1997.

  24. Chen, P.S., Alan Garfinkel, James N. Weiss and Hrayr S. Karagueuzian. Spirals, chaos, and new mechanisms of wave propagation. Pacing and Clinical Electrophysiology 20: 414-421, 1997.

  25. Kamjoo, K., T. Uchida, T. Ikeda, M. Fishbein, A. Garfinkel, J. Weiss, H. Karagueuzian, and P. Chen. The importance of location and timing of electrical stimuli in terminating sustained functional reentry in isolated swine ventricular tissue- evidence in support of a small reentrant circuit. Circulation 96:2048-2060, (1997)

  26. Kim Y-H, Garfinkel A, Ikeda T, Wu T-J, Athill CA, Weiss JN, Karagueuzian HS, Chen P-S. Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle: further evidence for the quasiperiodic route to chaos hypothesis. J Clin Invest. 100:2486-2500, 1997

  27. PS Chen, A Garfinkel, JN Weiss and H Karagueuzian. Computerized mapping of fibrillation in normal ventricular myocardium. Chaos 8: 127-136, 1998

  28. Withers-Ward ES; Jowett JB; Stewart SA; Xie YM; Garfinkel A; Shibagaki Y; Chow SA; Shah N; Hanaoka F; Sawitz DG, Chen, I.S.Y. Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. Journal of Virology, 1997 71(12):9732-42

  29. Bluhm, WF, Lew, WYW, Garfinkel, A, McCulloch, AD. Mechanisms of length history-dependent tension in an ionic model of the cardiac myocyte. Am. J. Physiol.-Heart and Circulatory Physiol., 43:H1032-H1040,1998

  30. CA Del Negro, CF Hsiao, SH Chandler and A Garfinkel. Evidence for a novel bursting mechanism in rodent trigeminal neurons. Biophys J. 75:174-182, 1998

  31. E Chudin, A Garfinkel, JN Weiss, W Karplus and B Kogan. Wave propagation in cardiac tissue and effects of intracellular calcium dynamics. Progress in Biophysics and Molecular Biology 69:225-236, 1998

  32. Wu TJ, Yashima M, Xie F, Athill CA, Kim Y-H, Fishbein MC, Qu Z, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S: The role of pectinate muscle bundles in the generation and maintenance of intraatrial reentry: implications for the mechanism of conversion between atrial fibrillation and atrial flutter. Circ Res 83:448-462 (and cover), 1998

  33. HM Hastings, SJ Evans, S Nangia, J Chin, M Smolow, O Nwasokwa, A Garfinkel. Ventricular fibrillation: one spiral or many? Proc. Roy. Soc. Lond B (Biological Sciences) 265: 2167-2170, 1998

  34. WF Bluhm, D Sung, WYW Lew, A Garfinkel, AD McCulloch. Cellular mechanism for the slow phase of the Frank-Starling response. J. Electrocardiology 31 Suppl. 13-22, 1998

  35. F Xie, Z. Qu, A Garfinkel. Dynamics of reentry around a circular obstacle in cardiac tissue. Phys. Rev. E 58:6355-6358, 1998

  36. Z Qu, J N Weiss, A Garfinkel. Cardiac restitution properties and the stability of reentrant spiral waves: a simulation study. Am. J. Physiol. 276: H269-H283 (and cover), 1999

  37. JN Weiss, A Garfinkel, HS Karagueuzian, Z Qu and PS Chen. Chaos and the transition to ventricular fibrillation: a new approach to anti-arrhythmic drug evaluation. Circulation 99:2819-2826, 1999.

  38. J Krivokapich, DO Walter, JS Child, A Garfinkel. Prognostic value of dobutamine stress echocardiography in predicting cardiac events in patients with known or suspected coronary artery disease. J.Am.Coll.Cardiol. 33:708-716 (1999)

  39. T Uchida, M Yashima, M Gotoh, Z Qu, A Garfinkel, JN Weiss, MC Fishbein, WJ Mandel, PS Chen, HS Karagueuzian. Mechanisms of acceleration of functional reentry in the ventricle: effects of ATP-sensitive Potassium channel opener. Circulation 99: 704-712 (1999)

  40. Ji-Min Cao, Zhilin Qu, Young-Hoon Kim, Tsu-Juey Wu, Alan Garfinkel, James N. Weiss, Hrayr S. Karagueuzian, Peng-Sheng Chen. Spatio-temporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: the importance of cardiac restitution properties Circ. Research 84:1318-1331 (1999)

  41. Z Qu and A Garfinkel. An advanced algorithm for solving partial differential equations in cardiac conduction. IEEE Transactions on Biomedical Engineering 46:1166-68 (1999)

  42. P Krogstad, C Uittenbogaart, R Dickover, YJ Bryson, S Plaeger and A Garfinkel. Primary HIV infection of infants: the effects of somatic growth on lymphocyte and virus dynamics. Clinical Immunology 92:25-33 (1999)

  43. Young-Hoon Kim, Fagen Xie, Masaaki Yashima, Tsu-Juey Wu, Miguel Valderrabano, Moon-Hyoung Lee, Toshihiko Ohara, Olga Voroshilovsky, Rahul Doshi, Michael C. Fishbein, Zhilin Qu, Alan Garfinkel, James N. Weiss, Hrayr S. Karagueuzian, Peng-Sheng Chen. Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle. Circulation 100: 1450-1459, 1999

  44. TJ Wu, M Yashima, R Doshi, YH Kim, CA Athill, JJC Ong, L Czer, A Trento, C Blanche, RM Kass, A Garfinkel, JN Weiss, MC Fishbein, HS Karagueuzian, PS Chen. Relation between the cellular repolarization characteristics and the critical mass for human ventricular fibrillation. J. Cardiac Electrophys. 10: 1077-86, 1999

  45. JI Goldhaber, ST Lamp, DO Walter, A Garfinkel, GH Fukumoto, J Weiss. Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange. J. Physiol. (Lond.) 520 (Part 2):431-8 (and cover), 1999

  46. Z. Qu, F. Xie, and A. Garfinkel. Diffusion-induced vortex filament instability in 3-Dimensional excitable media. Phys. Rev. Lett 83: 2668-2671, 1999

  47. Z. Qu, JN Weiss, and A Garfinkel. From local to global spatiotemporal chaos in a cardiac tissue model. Phys. Rev. E 61, 727-732, 2000

  48. S. Port, L. Demer, R. Jennrich, D. Walter and A. Garfinkel. Systolic blood pressure and mortality. The Lancet 355: 175-80, 2000.

  49. E. Chudin, J. Goldhaber, A. Garfinkel, J. Weiss, and B. Kogan. Intracellular Ca2+ Dynamics and the Stability of Ventricular Tachycardia. Biophys J 77: 2930-2941, 1999

  50. Zhilin Qu, Fagen Xie, James N. Weiss, and Alan Garfinkel. Origins of spiral wave meander and breakup in a 2-dimensional cardiac tissue model. Annals Biomed Eng. 28:755-771, 2000

  51. A Garfinkel, YH Kim, O Voroshilovsky, Z Qu, JR Kil, MH Lee, HS Karagueuzian, JN Weiss and PS Chen. Preventing ventricular fibrillation by flattening cardiac restitution. Proc. Nat Acad Sci. 97:6061-6066 (and cover), 2000

  52. Z Qu, J Kil, F Xie, J Weiss, A Garfinkel. Scroll Wave Dynamics in a 3D Cardiac Tissue Model: Roles of restitution, thickness and fiber rotation, Biophys J 78: 2761-2775, 2000

  53. Voroshilovsky O, Qu Z, Lee M-H, Ohara T, Fishbein GA, Huang H-L, Swerdlow CD, Lin S-F, Garfinkel A, Weiss JN, Karagueuzian HS, Chen P-S: Mechanisms of ventricular fibrillation induction by 60 Hz alternating current in isolated swine right ventricle. Circulation 102:1569-1574, 2000

  54. Edgerton, V. R., Roy, R. R., Hodgson, J. A., Day, M. K.,Weiss, J. Harkema, S. J., Dobkin, B., Garfinkel, A. , Konigsberg, E., Koslovskaya, I. How the science and engineering of spaceflight contribute to understanding the plasticity of spinal cord injury. Acta Astronautica 2000;47(1):51-62

  55. S Port, A Garfinkel, N Boyle. There is a nonlinear relationship between mortality and blood pressure. Eur. Heart J. 21(20):1635-1638. 2000

  56. Z Qu, A Garfinkel, P Chen, J Weiss. Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue Circulation 102(14):1664-1670 (2000)

  57. Hastings, H. M., Fenton, F. H., Evans, S. J., Hotomaroglu, O., Geetha, J., Gittelson, K., Nilson, J. Garfinkel, A. Alternans and the onset of ventricular fibrillation. Physical Review E 62:4043-4048 (2000)

  58. Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis. Arteriosclerosis, Thrombosis and Vascular Biology;20(11):2346-2348 (2000)

  59. Weiss JN, Chen PS, Qu ZL, Karagueuzian HS, Garfinkel A. Ventricular fibrillation - How do we stop the waves from breaking? Circulation Research 87(12):1103-1107 (2000)

  60. F Xie, Z Qu, J Weiss, A Garfinkel. Electrophysiologic heterogeneity and the stability of reentry in simulated cardiac tissue, Am. J. Physiol 280(2):H535-H545. (2001)

  61. Xie F, Qu Z, Garfinkel A, Weiss JN. Effects of simulated ischemia on spiral wave stability. Am J Physiol 280(4):H1667-73 (2001)

  62. Fagen Xie, Zhilin Qu, James N. Weiss, Alan Garfinkel: Coexistence of multiple spiral waves with independent frequencies in a heterogeneous excitable medium Phys Rev E 63: 031905-1 -- 031905-4 (2001)

  63. Lee MH, Qu Z, Fishbein GA, Lamp ST, Chang EH, Ohara T, Voroshilovsky O, Kil JR, Hamzei AR, Wang NC, Lin S-F, Weiss JN, Garfinkel A, Karagueuzian HS, Chen P-S: Patterns of wavebreak during ventricular fibrillation in isolated swine right ventricle. Am J Physiol 281:H253-265 (2001)

  64. Lee, M.-H., Lin, S.-F., Ohara, T., Omichi, C., Okuyama, Y., Chudin, E., Garfinkel, A. , Weiss, J. N., Karagueuzian, H. S., Chen, P.-S. Effects of diacetyl monoxime and cytochalasin D on ventricular fibrillation in swine right ventricles. Am. J. Physiol. 280:2689-2696 (2001)

  65. E Cherry, F Xie, Z Feliciano, A Garfinkel. Computer Modeling of Atrial Fibrillation. Cardiac Electrophysiology Review 5:271-276. (2001)

  66. C Omichi, S Zhou, MH Lee, A Naik, CM Chang, A Garfinkel, JN Weiss, SF Lin, HS Karagueuzian, PS Chen. Effects of Amiodarone on Wavefront Dynamics During Ventricular Fibrillation in Isolated Swine Right Ventricle. Am J Physiol 282:H1063-1070 (2002)

  67. Zengru Di, Zhilin Qu, James N. Weiss, and Alan Garfinkel. A Kinematic Study of Spiral Wave Drift in an External Electrical Field (submitted)

  68. Miguel Valderrábano, Junzhong Yang , Chikaya Omichi , John Kil , Scott T. Lamp Zhilin Qu , Shien-Fong Lin , Hrayr S. Karagueuzian , Alan Garfinkel , Peng-Sheng Chen , and James N. Weiss. Frequency Analysis of Ventricular Fibrillation in Swine Ventricles. Circulation Research 90:213-222 (2002)

  69. M Swissa, Z Qu, T Ohara, MH Lee, SF Lin, A Garfinkel, HS Karagueuzian, JN Weiss, PS Chen Action Potential Duration Restitution and Ventricular Fibrillation due to Rapid Focal Excitation Am J Physiol 282: H1915-1923 (2002)

  70. Weiss JN, Chen P-S, Qu Z, Karagueuzian HS, Garfinkel A: Electrical restitution and cardiac fibrillation. J Cardiovasc Electrophysiol 13:292-295 (2002)

  71. Xie F, Qu Z, Garfinkel A, Weiss JN. Electrical refractory period restitution and spiral wave reentry in simulated cardiac tissue. Am J Physiol Heart Circ Physiol. 283(1):H448-60. (2002)

  72. Garfinkel, A., Y. Tintut, D. Petrasek, K. Bostrom and L. L. Demer (2004). Pattern formation by vascular mesenchymal cells. Proc Natl Acad Sci U S A 101(25): 9247-50.

  73. Xie, F., Z. Qu, J. Yang, A. Baher, J. N. Weiss and A. Garfinkel (2004). A simulation study of the effects of cardiac anatomy in ventricular fibrillation. J Clin Invest 113(5): 686-93.

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