Curriculum Vitae
Research Interest
Our lab is studying basic mechanisms of
cardiac function that will enable us to develop therapeutic
strategies for protecting heart muscle during cardiac ischemia and
heart failure. Our current projects use patch clamp, laser scanning
confocal microscopy and transgenic techniques to study how cardiac
metabolism regulates excitation-contraction coupling, with
particular emphasis on the interaction between the L-type calcium
channel and the sodium-calcium exchanger. Cardiac metabolism is
regulated acutely during ischemia, and chronically by gene
expression during heart failure. We are also studying how
overexpression of the sodium-calcium exchanger protein leads to
hypertrophy and heart failure in a transgenic model. In another
project, we are studying how calcium movements participate in
arrhythmogenesis in normal heart. Clinical interests include the
role of metabolic support using GIK solution during ischemia and
heart failure, the role of rotating catheter sites to prevent
infectious complications in CCU patients, and the use of chest pain
centers in emergency rooms.
Representative Publications
Goldhaber, J.I., Xie, L., T. Duong, C.
Motter, K. Khuu, and J.N. Weiss. Action Potential Duration
Restitution and Alternans in Rabbit Ventricular Myocytes: The Key
Role of Intracellular Calcium Cycling. Circ. Res. 96:459-466.
2005.
Fukumoto, G.H., S.T. Lamp, C. Motter,
J. H. B. Bridge, A. Garfinkel and J.I. Goldhaber. Metabolic
inhibition alters subcellular calcium release patterns in rat
ventricular myocytes: implications for defective
excitation-contraction coupling during ischemia and reperfusion.
Circ. Res. 96: 551-557. 2005.
Imahashi K., C. Pott, J.I. Goldhaber,
C. Steenbergen, K.D. Philipson, E. Murphy, Cardiac-specific
ablation of the Na+/Ca2+ exchanger confers protection against
ischemia/reperfusion injury. Circ Res. 97: 916-921. 2005.
Pott, C., K. D. Philipson, and J. I.
Goldhaber, Reduced transarcolemmal calcium flux with increased E-C
coupling gain explains survival in Na+-Ca2+ exchange knockout
mice. Circ Res. 97: 1288-95. 2005.
Langenbacher AD, Dong Y, Shu XD, Choi
JY, Nicoll DA, Goldhaber JI, Philipson KD, Chen JN. Mutation in
sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in
zebrafish Proc. Natl. Acad. Sci. (USA) 102: 17699-17704. 2005.
Slesina M, Inman EM, Moore AE,
Goldhaber JI, Rome LH, Volknandt W. Movement of vault particles
visualized by GFP-tagged major vault protein. Cell Tissue Res.
324: 403-410. 2006. |
