Curriculum Vitae
Research Interest
My
research is focused on the derangements of the autonomic nervous
system, especially the sympathetic nervous system, in humans with
heart failure. I am currently studying the abnormal reflex responses
to exercise in heart failure patients, and how these contribute to
the overall exercise limitation in heart failure. We are testing the
hypothesis that exaggerated sympatho-excitatory responses to
exercise in heart failure are mediated by muscle mechanoreceptor
sensory nerves, which have been sensitized by ischemic metabolites.
A secondary focus of my research is on the effects of acupuncture on
the autonomic nervous system.
Representative Publications
Negrao CE, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD,
Middlekauff HR. Impaired endothelium - mediated vasodilation is
not the principle cause of elevated vascular resistance in heart
failure. Am J Physio1, 278: H168 - H174, 2000.
Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC,
Hage A, Moriguchi JD. Exaggerated renal vasoconstriction during
exercise in heart failure patients. Circulation, 101: 784 -
789, 2000.
Middlekauff HR, Doering A, Weiss JN. Adenosine enhances
neuroexcitability by inhibiting a slow post-spike after
hyperpolarization in rabbit vagal afferent neurons, Circulation
103:1325-29, 2001.
Negrao CE, Rondon MUPB, Tinucci T, Alves MJN, Roveda F, Braga AMW,
Reis SF, Nastari L, Barretto ACP, Krieger EM, Middlekauff HR.
Abnormal neurovascular control during exercise is linked to heart
failure severity, Am J Physiol Heart Circ Physiol
280:H1286-92, 2001.
Middlekauff HR, Yu JL, Hui, K. Acupuncture modulates reflex
responses to mental stress in humans, Am J Physiol Regul Integr
Comp Physiol 280:R1462-68, 2001.
Middlekauff HR, Nitzsche EU, Hoh
CK, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD. Exaggerated
muscle mechanoreflex control of reflex renal vasoconstriction in
heart failure, J Appl Physiol 90:1714-1719, 2001.
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