|
Curriculum Vitae
Research
Interest
Atherosclerosis, oral
mimetic peptides, functional assays for lipoproteins.
Representative
Publications
Reddy S, Hama S, Grijalva V, Hassan K, Mottahedeh R, Hough G,
Wadleigh DJ, Navab M, Fogelman AM. Mitogen-activated protein kinase
phosphatase 1 activity is necessary for oxidized phospholipids to induce
monocyte chemotactic activity in human aortic endothelial cells. J Biol
Chem. 2001, 276:17030-5.
Garber DW, Datta G, Chaddha M, Palgunachari
MN, Hama
SY, Navab M, Fogelman AM, Segrest JP, Anantharamaiah GM. A new
synthetic class A amphipathic peptide analogue protects mice from
diet-induced atherosclerosis. J Lipid Res. 2001, 42:545-52.
Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A,
Shih DM, Lusis AJ, Navab M, Fogelman AM. Human paraoxonase-3 is an
HDL-associated enzyme with biological activity similar to paraoxonase-1
protein but is not regulated by oxidized lipids. Arterioscler Thromb Vasc
Biol. 2001, 21:542-7.
Van Lenten BJ, Wagner AC, Nayak DP, Hama S, Navab M, Fogelman AM.
High-density lipoprotein loses its anti-inflammatory properties during
acute influenza a infection. Circulation. 2001,103:2283-8.
Dwyer JH, Navab M, Dwyer KM, Hassan K, Sun P, Shircore A,
Hama-Levy S, Hough G, Wang X, Drake T, Merz CN, Fogelman AM. Oxygenated
carotenoid lutein and progression of early atherosclerosis: the Los Angeles
atherosclerosis study. Circulation. 2001, 103:2922-7.
Datta G, Chaddha M, Hama S, Navab M, Fogelman AM, Garber DW,
Mishra VK, Epand RM, Epand RF, Lund-Katz S, Phillips MC, Segrest JP,
Anantharamaiah GM. Effects of increasing hydrophobicity on the
physical-chemical and biological properties of a class A amphipathic
helical peptide. J Lipid Res. 2001, 42:1096-104.
Navab M,
Hama SY,
Hough GP, Subbanagounder G, Reddy ST, Fogelman AM. A cell-free assay for
detecting HDL that is dysfunctional in preventing the formation of or
inactivating oxidized phospholipids. J Lipid Res. 2001, 42:1308-17.
Ng CJ, Wadleigh DJ, Gangopadhyay A, Hama S, Grijalva VR, Navab M,
Fogelman AM, Reddy ST. Paraoxonase-2 is a ubiquitously expressed protein
with antioxidant properties and is capable of preventing cell-mediated
oxidative modification of low density lipoprotein. J Biol Chem. 2001,
276:44444-9.
Honda HM, Hsiai T, Wortham CM, Chen M, Lin H, Navab M, Demer
LL. A complex flow pattern of low shear stress and flow reversal promotes
monocyte binding to endothelial cells. Atherosclerosis. 2001, 158:385-90.
Hsiai TK, Cho SK, Reddy S, Hama S, Navab M,
Demer LL, Honda HM, Ho CM. Pulsatile flow regulates monocyte adhesion to
oxidized lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol.
2001, 21:1770-6.
Navab M,
Anantharamaiah GM, Hama S, G arber DW, Chaddha M, Hough G, Lallone R,
Fogelman AM. Oral administration of an Apo
A-I mimetic Peptide synthesized from D-amino acids dramatically reduces
atherosclerosis in mice independent of plasma cholesterol. Circulation.
2002, 105:290-2.
Shi W, Wang X, Shih DM, Laubach VE, Navab M, Lusis AJ.
Paradoxical reduction of fatty streak formation in mice lacking endothelial
nitric oxide synthase. Circulation. 2002,105:2078-82.
Rahmani M, Raiszadeh F, Allahverdian S, Kiaii S, Navab M,
Azizi F. Coronary artery disease is associated with the ratio of
apolipoprotein A-I/B and serum concentration of apolipoprotein B, but not
with paraoxonase enzyme activity in Iranian subjects. Atherosclerosis.
2002, 162:381-9.
Hsiai TK, Cho SK, Honda HM, Hama S, Navab M,
Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows:
significance of high versus low shear stress slew rates (d(tau)/dt). Ann
Biomed Eng.
2002, 30:646-56.
Van Lenten BJ, Wagner AC, Anantharamaiah GM, Garber DW, Fishbein MC,
Adhikary L, Nayak DP, Hama S, Navab M, Fogelman AM. Influenza
infection promotes macrophage traffic into arteries of mice that is
prevented by D-4F, an apolipoprotein A-I mimetic peptide. Circulation.
2002, 106:1127-32.
|
