Mohamad Navab
Curriculum Vitae

 
Education

1976

Ph.D., Biochemistry
Columbia University, New York

1971

M.Sc., Biochemistry
Columbia University, New York

Positions

1995-present 

Professor, Project Leader
UCLA Division of Cardiology

1993-1995

Adjunct Associate Professor
UCLA Division of Cardiology

1989-1992

Associate Research Cardiologist
UCLA Division of Cardiology

1986-1989

Assistant Research Cardiologist
UCLA Division of Cardiology

1983-1986

Postgraduate Research Cardiologist
UCLA, Division of Cardiology

1982-1983

Research Associate, Department of Microbiology and Immunology
UCLA School of Medicine, Los Angeles

1980-1981

Acting Director Clinical Labs
Taleghani Medical Center
Assistant Professor, Department of Biochemistry
School of Medicine, University of Iran, Tehran

1979-1980

Deputy Director for Research, College of Nutrition Sciences
Institute of Nutrition, Iran, Tehran

1976-1980

Head, Department of Human Nutrition
Assistant Professor of Nutritional Biochemistry
Institute of Nutrition, Tehran

Honors

1997

UCLA Cardiology Faculty Award, by the Staff

1983-1986

National Institute of Health Post Doctoral Training Grant

1973-1976

Columbia University Col Phys&Surg Grad Stud Res Fellowship

1972-1976

Pahlavi Students Foundation, Graduate Student Fellowship

1971-1972

Columbia University SPHAM Grad Student Res Fellowship

Selected Publications

1. Navab, M., Mallia, A.K., Kanda, Y., Goodman, DeWS. Rat plasma prealbumin: isolation and partial characterization, J Biol Chem 252:5100-5106, 1977.

2. Navab, M., Smith, J.E., Goodman, DeWS. Rat plasma prealbumin: metabolic studies on effects of vitamin A status and on tissue distribution, J Biol Chem 252: 5107-5114, 1977.

3. Morrow, C.D., Navab, M., Peterson, C., Hoko, J., Dasgupta, A. Antibody to poliovirus genome-linked protein (VPg) precipitates in vitro synthesized RNA attached to Vpg- precursor polypeptide(s), Virus Res 1:89-100,1984.

4. Morrow, C.D., Hoko, J., Navab, M., Dasgupta, A. ATP is required for initiation of poliovirus RNA synthesis in vitro: Demonstration of tyrosinephosphate linkage between in vitro- synthesized RNA and Genom-linked protein, J Virol 50:515-523,1984.

5. Navab, M., Hough, G.P., Berliner, J.A., Fogelman, A.M., Haberland, M.E., Edwards, P.A. Rabbit-b-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance, J Clin Invest 78:389-397,1986.

6. Navab, M., Hough, G.P., Van Lenten, B.J., Berliner, J.A., Fogelman, A.M. Low density lipoproteins transfer bacterial lipopolysaccharides across endothelial monolayers in a biologically active form, J Clin Invest 81: 601-605,1988.

7. Thomas, D.D., Navab, M., Haake, D.A., Fogelman, A.M., Miller, N.J. and Lovett, M.A., Treponema pallidum invades intracellular junctions of endothelial cell monolayers, Proc Natl Acad Sci USA, 85:3608-3612,1988.

8. Navab, M., Hough G.P., Stevenson, L.W., Drinkwater, D.C., Laks, H. and Fogelman, A.M., Monocyte migration into the subendothelial space of a coculture of adult human aortic human endothelial and smooth muscle cells, J Clin Invest, 82:1853-1863,1988.

9. Rajavashisth, T. B., A. Andalibi, M. C. Territo, J. A. Berliner, M. Navab, A. M. Fogelman, and A. J. Lusis. Modified low density lipoproteins induce endothelial cell expression of granulocyte and macrophage colony stimulating factors. Nature (Lond.). 344:254-257. 1990.

10. Cushing, S. D., J. A. Berliner, A. J. Valente, M. C. Territo, M. Navab, F. Parhami, R. Gerrity, C. J. Schwartz, and A. M. Fogelman. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci USA, 87:5134-5138. 1990.

11. Navab, M., F. Liao, G. P. Hough, L. A. Ross, B. J. Van Lenten, T. B. Rajavashisth, A. J. Lusis, H. Laks, D. C. Drinkwater, and A. M. Fogelman. Interaction of monocytes with coculture of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message .J Clin Invest 87:1763-1772. 1991.

12. Liao, F., J. A. Berliner, M. Mehrabian, M. Navab, L. L. Demer, A. J. Lusis, and A. M. Fogelman. Minimally modified low density lipoprotein is biologically active in vivo in mice. J Clin Invest 87:2253-2257. 1991.

13. Navab M, Imes S, Hama SY, Hough GP, Ross LA, Bork RW, Valente AJ, Berliner JA, Drinkwater DC, Laks H, and Fogelman AM. Monocyte Transmigration Induced by Modification of LDL in Cocultures of Human Aortic Wall Cells is due to Induction of MCP- 1 Synthesis and is Abolished by HDL. J Clin Invest 88:2039-2046 1991.

14. Berliner JA, Navab M, Drake TA, and Fogelman AM. Do dietary fatty acids cause endothelial activation? How might endothelial activation contribute to thrombogenesis? Ame J Clin Nutr 56 (4 Suppl):804S, 1992.

15. Berliner JA, Territo M, Navab M, Andalibi A, Parhami F, Liao F, Kim J, Estworthy S, Lusis AJ, and Fogelman AM. Minimally modified lipoproteins in diabetes. Diabetes, 41 Suppl 2:74- 6, 1992.

16. Bennett RL, Navab M, Demer LL, Fogelman AM. A new anti-inflammatory leucine derivative, NPC-15669, inhibits growth of cultured human aortic smooth muscle cells. Arterioscler Thromb, 13:360-6, 1993.

17. Navab M, Hama SY, Van Lenten BJ, Drinkwater DC, Laks H, and Fogelman AM. A new anti-inflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human aortic wall cells. J Clin Invest 91:1225-30, 1993.

18. Reaven PD, Fergusen E, Navab M, and Powell FL. Susceptibility of human LDL to
    oxidative modification. Effects of variants in b-carotene concentration and oxygen tension.
    Arterioscler Thromb 14:1162-1169, 1994.

19. Watson AD, Navab M, Hama SY, Prescott SM, Stafforini DM, McIntyre TM, Fogelman AM and Berliner JA. Effect of platelet activating factor-acetyl hydrolase on production and action of minimally oxidized Low density lipoprotein. J Clin. Invest. 95:2104-2110. 1995.

20. Van Lenten BJ, Prieve J, Navab M, Hama SY, Lusis AJ, and Fogelman AM. Lipid-Induced Changes in Intracellular Iron Homeostasis in vitro and in vivo. J Clin Invest, 95:2104-2110. 1995.

21. Van Lenten BJ, Hama SY, deBeer FC, Stafforini DM, McIntyre TM, Prescott SM, La Du BN, Fogelman AM, Navab M. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest,96:2758-2767, 1995.

22. Watson AD, Berliner JA, Hama SY, La Du BN, Faull KF, Fogelman AM, Navab M. Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest ,96:2882- 2891, 1995.

23. Shih D, Gou J, Hama S, Navab M, Fogelman AM, and Lusis AJ, Serum paraoxonase regulation in genetic strains of mice on an atherogenic diet. J Clin Invest, 97:1630-1639, 1995.

24. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA and Fogelman AM. The yin and yang of the development of the fatty streak: A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscl Thromb & Vascul Biol, 16:831-842, 1996.

25. Watson AD, Leitinger N, Navab M, et al. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem, 272:13597-13607, 1997.

26. Navab M, Hama-Levy S, Van Lenten BJ, Fonarow GC, Cardinez CJ, Hough G, Castellani LW, Brennan M-L, La Du BN, Lusis AJ, Fogelman AM. Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio. J Clin Invest, 99:2005-2019, 1997.

27. Castellani L, Navab M, Hama S, Hedrick CC, and Lusis AJ, Overexpression of apolipoprotein AII in mice converts high density lipoprotein to a pro-inflammatory particle. J Clin Invest, 100:464-474, 1997.

28. Ishikawa, K, Navab, M, Leitinger, N, Fogelman, AM, and Lusis AJ. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J Clin Invest, 100:1209-1216, 1997.

29. Pervin, S, R Singh, M Rosenfeld, M Navab, G Chudhuri, , L Nathan. Estradiol suppresses MCP-1 expression in vivo: implications for atherosclerosis. Arterioscl Thromb & Vascul Biol,
    18:1575-1582, 1998.

30. Shih, D, X-P Wang, Hama S, Navab M, Fogelman AM, And Lusis AJ. Mice lacking serum Paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 394:284-287, 1998.

31. B. Ivandic, L. Castellani, X-P Wang, J-H Qiao, M Mehrabian, M Navab, A M. Fogelman, D S. Grass, M E. Swanson, M C. de Beer, F de Beer, A J Lusis. Role of group II secretory PLA2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group II phospholipase A2. Arterioscl Thromb & Vascul Biol. 19:1284-1290, 1999.

32. Leitinger N, Navab M, Fogelman AM, Lusis AJ and Berliner JA. Role of group II secretory PLA2 in atherosclerosis: 2. Mechanism of lipid oxidation. Arterioscl Thromb & Vascul Biol. 19:1291-1298, 1999.

33. La Du, BN, M. Aviram, S. Billecke, M. Navab, SL Primo-Parmo, RC Sorenson, and TJ Standiford. On the physiological roles of the paraoxonases. Chem.-Biol. Interact. 119-120:379-388, 1999.

34. Lee C, Sigari F, Segrado T, Horkko S, Hama S, Subbaiah PV, Miwa M, Navab M, Witztum JL, Reaven PD. All ApoB-containing lipoproteins induce monocyte chemotaxis and adhesion when minimally modified. Modulation of lipoprotein bioactivity by platelet-activating factor acetylhydrolase. Arterioscl Thromb & Vascul Biol 19:1437-1446, 1999.

35. Honda HM, Wakamatsu BK, Goldhaber JI, Berliner JA, Navab M, Weiss JN. High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells. Atherosclerosis, 143:299-306, 1999.

36. Watson AD, Subbanagounder G, Welsbie DS, Faull KF, Navab M, Jung ME, Fogelman AM, Berliner JA. Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein. J Biol Chem. 274:24787-98, 1999.

37. Hedrick CC, Hassan K, Hough GP, Yoo JH, Simzar S, Quinto CR, Kim SM, Dooley A, Langi S, Hama SY, Navab M, Witztum JL, Fogelman AM. Short-term feeding of atherogenic diet to mice results in reduction of HDL and paraoxonase that may be mediated by an immune mechanism. Arterioscler Thromb Vasc Biol. 2000, 20:1946-52.

38. Navab M, Hama SY, Cooke CJ, Anantharamaiah GM, Chaddha M, Jin L, Subbanagounder G, Faull KF, Reddy ST, Miller NE, Fogelman AM. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. J Lipid Res. 2000, 41:1481-94.

39. Navab M, Hama SY, Anantharamaiah GM, Hassan K, Hough GP, Watson AD, Reddy ST, Sevanian A, Fonarow GC, Fogelman AM. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. J Lipid Res. 2000, 41:1495-508.

40. Van Lenten BJ, Wagner AC, Navab M, Fogelman AM. Oxidized phospholipids induce changes in hepatic paraoxonase and ApoJ but not monocyte chemoattractant protein-1 via interleukin-6. J Biol Chem. 2001, 276:1923-9.

41. Mehrabian M, Castellani LW, Wen PZ, Wong J, Rithaporn T, Hama SY, Hough GP, Johnson D, Albers JJ, Mottino GA, Frank JS, Navab M, Fogelman AM, Lusis AJ. Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J). J Lipid Res. 2000, 41:1936-46.

42. Reddy S, Hama S, Grijalva V, Hassan K, Mottahedeh R, Hough G, Wadleigh DJ, Navab M, Fogelman AM. Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells. J Biol Chem. 2001, 276:17030-5.

43. Garber DW, Datta G, Chaddha M, Palgunachari MN, Hama SY, Navab M, Fogelman AM, Segrest JP, Anantharamaiah GM. A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis. J Lipid Res. 2001, 42:545-52.

44. Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM. Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. Arterioscler Thromb Vasc Biol. 2001, 21:542-7.

45. Van Lenten BJ, Wagner AC, Nayak DP, Hama S, Navab M, Fogelman AM. High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection. Circulation. 2001,103:2283-8.

46. Dwyer JH, Navab M, Dwyer KM, Hassan K, Sun P, Shircore A, Hama-Levy S, Hough G, Wang X, Drake T, Merz CN, Fogelman AM. Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study. Circulation. 2001, 103:2922-7.

47. Datta G, Chaddha M, Hama S, Navab M, Fogelman AM, Garber DW, Mishra VK, Epand RM, Epand RF, Lund-Katz S, Phillips MC, Segrest JP, Anantharamaiah GM. Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide. J Lipid Res. 2001, 42:1096-104.

48. Navab M, Hama SY, Hough GP, Subbanagounder G, Reddy ST, Fogelman AM. A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids. J Lipid Res. 2001, 42:1308-17.

49. Ng CJ, Wadleigh DJ, Gangopadhyay A, Hama S, Grijalva VR, Navab M, Fogelman AM, Reddy ST. Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem. 2001, 276:44444-9.

50. Honda HM, Hsiai T, Wortham CM, Chen M, Lin H, Navab M, Demer LL. A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells. Atherosclerosis. 2001, 158:385-90.

51. Hsiai TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM. Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol. 2001, 21:1770-6.

52. Navab M, Anantharamaiah GM, Hama S, G arber DW, Chaddha M, Hough G, Lallone R, Fogelman AM. Oral administration of an Apo A-I mimetic Peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol. Circulation. 2002, 105:290-2.

53. Shi W, Wang X, Shih DM, Laubach VE, Navab M, Lusis AJ. Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase. Circulation. 2002,105:2078-82.

54. Rahmani M, Raiszadeh F, Allahverdian S, Kiaii S, Navab M, Azizi F. Coronary artery disease is associated with the ratio of apolipoprotein A-I/B and serum concentration of apolipoprotein B, but not with paraoxonase enzyme activity in Iranian subjects. Atherosclerosis. 2002, 162:381-9.

55. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt). Ann Biomed Eng. 2002, 30:646-56.

56. Van Lenten BJ, Wagner AC, Anantharamaiah GM, Garber DW, Fishbein MC, Adhikary L, Nayak DP, Hama S, Navab M, Fogelman AM. Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide. Circulation. 2002, 106:1127-32.

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