Research Summary
Our research
program focuses on the characterization of signaling pathways and
cellular organelles in the heart, with a particular interest on
alterations of subproteomes during myocardial ischemic injury.
Since 1992, this research program has authored 90 manuscripts in
cardiac cell signaling and myocardial ischemic injury. The
functional proteomic approaches we employ have provided key
information pertaining to the proteomic basis of diseased cardiac
phenotypes, and enabled a holistic portrait of multiple molecules
and pathways in parallel. The proteomic delineation combined with
genetic interrogations has been effective to gain pathogenic
insights in heart diseases. Dr. Peipei Ping, the Director of our
research program, is the principal investigator of an NHLBI
Program Project Award on Myocardial Ischemic Injury and
Protection. For additional information please visit our website at
www.signalingmodules.org
.
Representative
Publications
Lu H, Zong C, Wang Y, Young
GW, Deng N, Souda P, Li X, Whitelegge J, Drews O, Yang PY,
Ping P. "Revealing the dynamics of 20S
proteasome phosphoproteome: A combined CID and ETD approach." Mol Cell
Proteomics. (In Press) (2008)
Zhang J, Li X,
MuJames N. Weiss, Paavo Korge, Henry M. Honda, Peipei Pingeller M,
Wang YJ, Zong C, Deng N, Vondriska TM, Liem DA, Yang YJ, Korge P,
Honda H, Weiss JN, Apweiler R, Ping P.
“Systematic Characterization of the Murine Mitochondrial Proteome
Using Functionally Validated Cardiac Mitochondria”. Proteomics
8(8):1564-1575 (2008)
Zhang J, Liem DA, Mueller
M, Wang YJ, Zong C, Deng D, Vondriska TM, Korge P, Drews O, MacLellan WR,
Honda H, Weiss JN, Apweiler R, Ping P.
“Altered Proteome Biology of Cardiac Mitochondria Under Stress
Conditions”. J Proteome Res. (In Press) (2008)
Taylor CF, Paton NW, Lilley
KS, Binz PA, Julian RK Jr, Jones AR, Zhu W, Apweiler R, Aebersold R,
Deutsch EW, Dunn MJ, Heck AJ, Leitner A, Macht M, Mann M, Martens L,
Neubert TA, Patterson SD, Ping P,
Seymour SL, Souda P, Tsugita A, Vandekerckhove J, Vondriska TM, Whitelegge
JP, Wilkins MR, Xenarios I, Yates JR 3rd, Hermjakob H. “The Minimum
Information about a Proteomics Experiment (MIAPE)”. Nat Biotechnol.,
25: 887-893 (2007)
Drews O, Wildgruber R, Zong
C, Sukop U, Nissum M, Weber G, Gomes AV, Ping P.
“Mammalian Proteasome Subpopulations with Distinct Molecular Compositions
and Proteolytic Activities”. Mol Cell Proteomics., 6: 2021-2031
(2007)
Gomes AV, Zong C, Edmondson
RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X,
Bardag-Gorce F, Ping P. “Mapping the
Murine Cardiac 26S Proteasome Complexes”. Circ Res., 99: 362-371
(2006)
Zong C, Gomes AV, Drews O,
Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F,
Ping P. “Regulation of Murine Cardiac 20S
Proteasomes: Role of Associating Partners”. Circ Res., 99: 372-380
(2006)
Weiss JN, Korge P, Honda
HM, Ping P. “Role of the Mitochondrial Permeability Transition in
Myocardial Disease”. Circ Res., 93: 292-301 (2003)
Edmondson RD, Vondriska TM,
Biederman KJ, Zhang J, Jones RC, Zheng Y, Allen DL, Xiu JX, Cardwell EM,
Pisano MR, Ping P. PKC signaling complexes include metabolism- and
transcription/translation-related proteins: complimentary separation
techniques with liquid chromatography and tandem mass spectrometry. Mol
Cell Proteomics. 2002;1:421-433.
Baines PC, Zhang J, Wang
GW,
Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P. Mitochondrial PKC
and MAPK form signaling modules in the murine heart. Circ Res. 2002;90:390-397.
Balafanova Z, Bolli R, Pass
JM, Wang O, Zhang J, Gao J, Bhatnagar A, Ping P. Nitric oxide
donors induce nitration of PKC , facilitating PKC translocation via
enhanced PKC -RACK2 interactions: a novel mechanism of NO-triggered
activation of PKC. J Biol Chem 2002;277:15021-15027.
Ping P, Song C,
Zhang J, Guo Y, Cao X, Li R, Wu W, Vondriska TM, Pass JM, Tang XL, Pierce
WM, Bolli R. Formation of PKC -Lck signaling modules confers
cardioprotection. J Clin Invest 2002;109:499-507.
Song C, Vondriska TM, Wang
GW, Klein JB, Cao X, Zhang J, Kang Y, D'Souza S, Ping P. Molecular
conformation dictates module formation: example of PKC and Src tyrosine
kinase. Am J Physiol 2002;282:H1166-H1171.
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