Curriculum
Vitae
Research
Interest
Current research
areas include:
-
Molecular
basis of abnormal excitation-contraction coupling in
hypertrophic and idiopathic dilated cardiomypathy, and
congestive heart failure using genetic, molecular biology,
electrophysiologic, biochemical approaches.
-
Efficiency,
efficacy and adverse effect of ex vivo and in vivo gene
therapy in heart transplantation and congestive hear failure.
-
Heterogeneity
of cardiac depolarization and repolarization in the mechanism
of atrial and ventricular arrhythmias using Monophasic action
potential mapping technique.
-
Thyroid
hormones effect on cardiac electrophysiological properties
using patch clamp, molecular biology techniques.
Representative
Publications
Sen
L,*, Hong
Y-S, Luo H, Cui G, Laks H: Efficiency, efficacy and adverse
effects of adenovirus versus liposome-mediated gene thearpy in
cardiac allografts. Am J Physiol 2001;281:H1433-1441
Cui
G, Kobashigawa J, Laks L, Sen L* : Increased incidence of
atrial flutter associated with the rejection of heart
transplantation. Am J Cardiol 2001;88:280-284.
Oshima
K, Sen L, Cui G, Tung T, Sacks BM, Arellano-Kruse A, Laks
H: Localized interleukin-10 gene transfer induces apoptosis of
alloreactive T cells via Fas/FasL pathway improves function and
prolongs survival of cardiac allografts. Transplantation
2002;74:1019-1026
Sen
L* , Cui G,
Sakaguchi Y, Zhou L-M, Singh BN: Acute effects of zatebradine on
cardiac conduction and repolarization in anesthetized dogs. J
Pharm Exp Therap 2002;7(1):29-38.
Hong
Y-S, Sen L* , Cui G, Nonoyam M, Chong T, Laks L: The
Mechanism of localized immunosuppression in the cardiac allograft
induced by liposome-mediated IL-10 gene therapy. J Heart Lung
Transpl 2002;
Sen
L* ,
Sakaguchi Y, Cui G: T3 increase Na+ current in adult guinea-pig
ventricular myocyte and possible role of GTP-binding protein(s).
Am J Physiology 2002;
Tung
T, Oshima K, Laks H, Cui G, Sen L* : Distinct difference in
the tissue distribution of the apoptosis regulatory proteins Bcl-2
and Bcl-XL. Am J Physiol 2002;
Tung
T, Cui G, Oshima K, Laks H, Sen L* : Profile of apoptosis
regulatory proteins in chronic rejection of cardiac allografts. Am
J Pathol 2002
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